The Formation of Plasma Lipoproteins from Apoprotein in Plasma.

In a previous paper (1) we reported that, when livers from rats fed diets containing 2% cholesterol were perfused with whole blood from normal rats, the concentration of cholesterol and triglyceride in the perfusate increased significantly. These lipids were present almost entirely in the lipoproteins of density (d) < 1.019. In the present investigations the transfer of lipids from the liver into the plasma in the form of lipoproteins has been studied in more detail. We have found that specific plasma proteins participate in the transfer of lipids by combining with lipid in the liver to form lipoproteins. Preliminary reports of this work have been published (24).